Guillain–Barré syndrome (GBS) (French pronunciation: [ɡiˈlɛ̃ baˈʁe], English pronunciation: /ɡiːˈjænbɑrˈeɪ/), sometimes Guillain–Barré–Strohl syndrome or Landry’s paralysis, is a medical condition in which there is a rapid-onset weakness of the limbs as a result of an acute polyneuropathy, a disorder affecting the peripheral nervous system. The disease is usually triggered by an infection, which provokes immune-mediated nerve dysfunction. Many experience changes in sensation or develop pain, followed by muscle weakness beginning in the feet and hands that develops rapidly (between half a day and two weeks). During the acute phase, the disorder can be life-threatening with about a quarter requiring admission to intensive care unit for mechanical ventilation. Some are affected by fluctuations in the function of the autonomic nervous system, which can lead to dangerous abnormalities in heart rate and blood pressure.